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Because a chemical may produce more thanone toxic effect, the first step is to identify from the avail-able data the adverse effect that occurs at the lowest dose.Second, the threshold dose or some surrogate measureof the threshold dose (e.g., the nOAeL or LOAeL reducedby some amount) is identified for the most sensitive toxicendpoint. Ina recent meta-analysis for prediction of angiographic vasospasm, the sensitivity of CTP was74%, with 93% sensitivity. Postanesthetic hyperthermia in cats: a retrospective comparisonbetween hydromorphone and buprenorphine. The pedunculopontine nucleus has also beenconsidered a possible target (Stefani et al. Lyrica order form 2007). Time course for autoregulation recovery following severetraumatic brain injury

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